This project investigates how specific neural circuits and cell types contribute to taste memory formation, focusing on the role of eIF2α-mediated mRNA translation. Researchers aim to decode how the insular cortex, medial prefrontal cortex, and basolateral amygdala work together to consolidate taste memories by regulating protein synthesis at the molecular level. Using advanced tools like retrograde tracing, Ribotag sequencing, and genetically modified mice, the study will map how neurons activate and translate specific mRNAs in response to novel, familiar, and aversive taste experiences.

Findings from this project will help uncover how targeted protein synthesis within brain circuits supports long-term memory formation. These insights could guide future treatments for memory impairments related to aging and neurodegenerative diseases.