Maintaining balance within a cell is critical to human health, especially during development, when errors can lead to aggressive pediatric cancers. This project explores how two key tumour suppressor proteins, Tuberin and Hamartin, regulate cell division under normal and stress conditions. Using a cutting-edge technique called BioID, researchers will map the network of proteins that interact with these tumour suppressors during key phases of the cell cycle, providing insight into why certain childhood cancers arise and behave more aggressively. 

This research will reveal how tumour suppressor proteins respond to stress signals like nutrient deprivation or DNA damage to control cell growth. Findings could inform the design of targeted, less toxic treatments for rare and pediatric cancers where current therapies are limited.