Outcomes of Hospitalized Glioblastoma Patients Receiving Radiation-Based Treatment: A Retrospective Cohort Study at Windsor Regional Cancer Centre

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Outcomes of Hospitalized Glioblastoma Patients Receiving Radiation-Based Treatment: A Retrospective Cohort Study at Windsor Regional Cancer Centre

Outcomes of Hospitalized Glioblastoma Patients Receiving Radiation-Based Treatment: A Retrospective Cohort Study at Windsor Regional Cancer Centre

Deya'a Almasri
Schulich School of Medicine & Dentistry

FUNDER: Schulich-Windsor Campus Opportunities for Research Excellence Program (SWORP)

GRANT DURATION: 2026-2027

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Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults, carrying a median survival of 14–16 months even with optimal therapy. A clinically important and understudied population are GBM patients who are sufficiently ill at presentation that they never leave hospital after diagnosis, either because post-surgical complications or functional decline prevent discharge, or because their disease is unresectable and initial management requires prolonged inpatient care. This retrospective cohort study will examine the clinical outcomes of inpatient GBM patients treated at Windsor Regional Cancer Centre (WRCC) who received radiation-based treatment, either adjuvant chemoradiotherapy (temozolomide + radiation) following surgical resection, or primary chemoradiotherapy for unresectable disease, without ever being discharged to home or a rehabilitation facility between diagnosis and treatment initiation. The primary objective is to characterize overall survival (OS), treatment completion rates, and functional outcomes in this population. Secondary objectives include identifying predictors of treatment futility, quantifying acute toxicity burden, and evaluating rates of transitions to palliative/comfort care. Findings will have a direct, immediate impact on care at the Cancer Centre as it will inform treatment decisions going forward including appropriate patient selection for aggressive therapy, and inpatient resource utilization at WRH.
This study is expected to generate: a descriptive profile of inpatient-treated GBM patients at WRCC; survival curves and OS estimates for both treatment cohorts; a multivariable predictive model for outcomes; and a set of evidence-based recommendations to guide inpatient GBM treatment decisions. Results will be submitted for presentation at a regional or national oncology meeting (e.g., WeSpark, ASCO) and prepared as a manuscript for peer-reviewed publication.

CO-INVESTIGATORS

Windsor Regional Hospital

  • Dr. Abdullah Nasser
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