Evaluation of a Continuous Glucose Monitor in Patients with Diabetes on Peritoneal Dialysis

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Evaluation of a Continuous Glucose Monitor in Patients with Diabetes on Peritoneal Dialysis

Evaluation of a Continuous Glucose Monitor in Patients with Diabetes on Peritoneal Dialysis

Amina Choudhry
Schulich School of Medicine & Dentistry

FUNDER: Schulich-Windsor Campus Opportunities for Research Excellence Program (SWORP)

GRANT DURATION: 2026-2027

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Achieving adequate glycemic control in patients with diabetes undergoing peritoneal dialysis (PD) is particularly challenging. Physiological changes associated with end-stage kidney disease (ESKD), including altered insulin metabolism, impaired insulin clearance, and exposure to glucose-containing dialysate, can result in significant fluctuations in blood glucose levels. These fluctuations contribute to both hypoglycemia and hyperglycemia and increase the risk of cardiovascular complications in this population (Jakubowska & Malyszko, 2024; Li et al., 2022). Continuous glucose monitoring (CGM) systems provide a promising alternative to intermittent finger-prick glucose testing by measuring interstitial glucose levels continuously. These systems allow better assessment of glucose variability, detect asymptomatic hypoglycemia, and monitor time-in-range metrics (Bomholt et al., 2023; Zhang et al., 2024). However, despite increasing clinical adoption, CGM devices have not been formally validated for use in patients undergoing dialysis, particularly those receiving PD. The objective of this study is to evaluate the accuracy of the FreeStyle Libre 3 CGM system in adults with diabetes undergoing PD at Windsor Regional Hospital. Participants will wear the sensor for 14 days while simultaneously performing capillary blood glucose measurements using a glucometer. Paired glucose readings will be compared to determine the accuracy of the CGM system. We hypothesize that the FreeStyle Libre 3 system will demonstrate acceptable accuracy when compared with glucometer measurements in patients with diabetes undergoing PD. Findings from this study will help determine whether CGM technology may be a reliable tool for glucose monitoring in this patient population and could inform future clinical practice.
This study is expected to provide important preliminary evidence regarding the accuracy and clinical utility of the FreeStyle Libre 3 CGM system in adults with diabetes undergoing PD. By comparing interstitial glucose measurements obtained from the CGM device with capillary blood glucose values obtained through finger-prick testing, this study will determine whether the device demonstrates acceptable accuracy in this population.

CO-INVESTIGATORS

Windsor Regional Hospital

  • Dr. Amit Bagga
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