Though cancer research has made great strides to improve patient outcome and survival, metastatic cancer remains largely untreatable and fatal. Being able to predict metastasis easily and accurately in an in vivo research model is a crucial step in finding better treatment options for these patients. Our innovative zebrafish platform uses assays that maintain the elements of the microenvironment of a cancer patient to allow for metastatic prediction of patient cells. Zebrafish are an excellent research model for studying cell metastasis because of small embryo size and transparent bodies.
Zebrafish have also been emerging as a potential system to screen compounds and treatment options prior to administering them directly to the patient. Using the previously developed zebrafish xenograft system, cells can be transplanted into embryos and after engraftment has occurred, the embryos can be assayed into a high throughput array plate for drug treatments. Fish are monitored before and after treatment and analysed for drug efficacy or drug toxicity. Many drugs can by assayed at once, saving a lot of time and money.